Association of Polyaminergic Loci With Anxiety, Mood Disorders, and Attempted Suicide

The authors genotyped 63 polymorphisms, across 4 polyaminergic genes, in 1255 French-Canadian individuals, followed longitudinally for 22 years. Univariate associations with anxiety, mood disorders, & attempted suicide as assessed in early adulthood were examined. The involvement of gene-environment interactons in terms of childhood abuse were investigated & internalizing & externalizing symptoms as endophenotypes mediating these[…]

Serum Typtophan Ration and Suicidal Behavior in Adolescents: a Prospective Study

The purpose of this study was to conduct the first prospective examination of the utility of the tryptophan ratio along with clinical variables in predicting suicidal behavior in high-risk & reference adolescents. Adolescents with alcohol use disorders (AUD) & prior suicidal attempts, those with AUDs & without suicide attempts, & community controls with neither of[…]

Biogenic Amine Turnover and Serum Cholesterol in Suicide Attempt

This study examined biological correlates of suicidal behavior. In a sample of 111 suicide attempters admitted to a Greek general hospital, the authors studied the turnover of neurotransmitters by measuring the urinary output of the main metabolites of serotonin, dopamine, noradrenaline & serum cholesterol, & compared them to 62 healthy controls. Urinary noradrenaline was significantly[…]

Suicide as an Indicium of Biologically-Based Brain Disease

Suicide is not an illness; it is a behaviour that may in some instances be a symptom of a psychiatric disorder or an indicant of impulsivity resulting from neuropharmacologic changes that are genetically determined. Slaby reviews the literature supporting the fact that suicide results from biologically-based brain disease & outlines avenues of research to further[…]

Monoamines and Suicidal Behavior (IN: Violence and Suicidality: Perspectives in Clinical and Psychobiological Research, edited by H M van Praag, R Plutchik & A Apter)

This chapter presents a comprehensive review of studies & indicates there is now a great deal of evidence suggesting that disturbance of monoamine regulation may play a role in suicidal behavior. Decreased serotonin turnover has been strongly implicated, particularly in relation to impulsive & violent behavior. The need for further studies & possible areas of[…]

Genetic and Biologic Risk Factors for Suicide in Depressive Disorders

Recent data suggests there may be genetic & biologic risk factors for suicide. This paper reviews studies from clinical populations, twins, the Amish, as well as data from the Iowa-500 & Danish-American adoption studies which suggest that there may be a genetic factor predisposing to suicide. This paper also reviews neurochemical data from cerebrospinal fluid,[…]

Clinical Applications of Biological Aspects of Suicide (IN: Suicide: Guidelines for Assessment, Management, and Treatment, edited by B Bongar)

Author provides an updated overview of 15 biological measures & considerations with potential clinical use for risk assessment & suicide prevention. The most consistent candidate for potentail use has been serotonin and its metabolite 5-hydroxyindoleacetic acid. None of the measures developed to date have clear and present role in suicide risk assessment. Author concludes that[…]

Psychopharmacotherapy of Suicidal Ideation and Behavior (IN: Suicide: Guidelines for Assessment, Management, and Treatment, edited by B Bongar)

This chapter reviews the neurochemical basis of violent behavior including amines & their metabolites, receptor binding & other neuroendocrine measures, & reports on medication use. Impulsive violent behavior is more associated with disturbances of serotonin metabolism than disorders of mood. Not all suicidal behavior is psychopharmacologically responsive. Psychopharmacotherapy must be supplemted by other therapeutic interventions[…]

The Role of Monoamines in Suicidal Behavior

This study looks at the role monoamine levels, i.e. serotonin, play in suicidal behaviour. The findings, some of which are in contrast to what has usually been found, indicate that other aspects than diagnosis or suicide attempt method must be taken into consideration when performing amine metabolite studies: for example, other biochemical factors, impulsivity and[…]

Increased Soluble Interleukin-2 Receptor Concentrations in Suicide Attempters

Several biochemical parameters such as monoamines and corticosteroids are considered to play a role in the underlying pathogenetic mechanisms in mood disorders. It has also been proposed that disturbances of the immune system may be responsible for mental disorders. This study clearly shows that an imbalance of the immune system was present in psychiatric patients[…]