Alterations in Monoamine Receptors in the Brain of Suicide Victims

Using in vitro quantitative receptor autoradiography, the binding of 125 I-lysergic acid diethylamide & 125 I-pindolol was compared with slide-mounted sections from the prefrontal & the temporal cortex of a group of suicide victims, matched to control specimens. Binding to both 125 I-lysergic acid diethylamide & 125 I-pindolol was increased in the prefrontal cortex of the suicide victims, whereas only B-adrenergic binding was increased in the temporal cortex of the suicide group. (35 refs.)