Prevalence of suicide attempts and their risk factors in school-aged patients with epilepsy: A population-based study.

Suicide prevention is a critical issue for young people. However, no large body of representative data on the risk of suicide attempts in school-aged patients with epilepsy in Taiwan or other developing countries is available. Patients aged ≤ 18 years who received a diagnosis of epilepsy between 2000 and 2012 were included in the epilepsy cohort (N = 9801). The […]

Epilepsy and suicidality: What’s the relationship?

IMPORTANCE: People with epilepsy have a 5-fold increased risk of suicide. Less is known about attempted suicide and whether psychiatric disorders and antiepileptic drugs modify the risk of attempted suicide. OBJECTIVES: To estimate the magnitude of the association between attempted suicide and epilepsy by comparing a first suicide attempt and a second suicide attempt (hereafter […]

Suicide among people with epilepsy: A population-based analysis of data from the U.S. National Violent Death Reporting System, 17 states, 2003-2011.

Highlights We examined suicide burden among people with epilepsy in 17 U.S. states (2003Ð2011). The estimated average annual suicide rate in those with epilepsy was 16.89/100,000 persons. Suicide risk in those with epilepsy was 22% higher than in the general population. Suicides occurred more often in residence, among those 40Ð49 years old, and by poisoning. […]

Suicidal risk, affective dysphoric disorders, and quality-of-life perception in patients with focal refractory epilepsy.

Highlights ¥ Evaluation the association among quality of life, affective disorders and suicidal risk. ¥ Affective somatoform dysphoric disorder and severity of the depressive disorder are related to suicidal risk. ¥ Lower quality of life is a predictor of an increase in suicidal risk. Contact us for a copy of this article, or view online […]

Occurrence and recurrence of attempted suicide among people with epilepsy.

Objectives To estimate the magnitude of the association between attempted suicide and epilepsy by comparing a first suicide attempt and a second suicide attempt (hereafter referred to as a recurrent suicide attempt) among people before they received a diagnosis of epilepsy (case patients) with a first suicide attempt and a recurrent suicide attempt among people […]

Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on therapeutic strategies of the ILAE Commission on neuropsychobiology.

In 2008, the U.S. Food and Drug Administration (FDA) issued an alert to health care professionals about an increased risk of suicide ideation and suicide behavior in people treated with antiepileptic drugs (AEDs). Since then, a number of retrospective cohort and case-control studies have been published that are trying to address this issue, but gathered […]

Suicidal ideation and behavior screening in intractable focal epilepsy eligible for drug trials.


Assessing Suicidal Risk With Antiepileptic Drugs

The authors discuss the issue of suicide in epilepsy with special attention to antiepileptic drugs & the assessment of suicide in people with epilepsy. It has been suggested that early medical treatment with antiepileptic drugs might potentially reduce suicide risk in people with epilepsy, but it is of great importance that the choice of drugs […]

Antiepileptic Drugs and Suicidality

In this article, the association of epilepsy & antiepileptic drugs with psychiatric disease & suicidality are reviewed, perspective as to the significance & limitations of the American Food and Drug Administration’s findings are discussed, & some options for suicidality screening & their potential utility in clinical care are evaluated. (76 refs.) JA

Suicide in People With Epilepsy: how Great is the Risk?

A meta-analysis was done to estimate the risk of suicide in people with epilepsy. Standardized mortality ratios with 95 percent confidence intervals were calculated for each cohort, for groups of cohorts, & for the total population. The overall standardized mortality ratio was 3.3 based on 190 observed suicides compared with 58.4 expected. This ratio was […]

Wisconsin Card Sorting Test Performance and Impulsivity in Patients With Temporal Lobe Epilepsy: Suicidal Risk and Suicide Attempts

This study determined if executive function & impulsivity are related to risk for suicide & suicide attempts in patients with temporal lobe epilepsy. 42 patiens were recruited. Mutliple regression analysis was carried out to examine predictive associations between clinical variables & Wisconsin Card Sorting Test measures. 24 patients had a score on the Risk for […]

Death in Epilepsy With Special Attention to Suicide Cases

The records of 43 deceased patients with well-classified epilepsy were analyzed, with special attention to cases of suicide. The subjects were compared with 1722 control patients who had showed definite subtypes of epilepsy. 6 patients died by suicide. There were no significant differences with regard to clinical variables except for psychotic episodes, which were more […]

Antiepileptic Drugs and Risk of Suicide: a Nationwide Study

This study investigated possible differences in suicide risk associated with different antiepileptic drugs. The use of antiepileptic drugs in the Danish population from 1997-2006 was determined by prescription claims. The risk of suicide associated with the use of antiepileptic drugs was estimated by case-crossover analyses, where each case serves as its own control during different […]

Suicidality and Epilepsy: a Complex Relationship That Remains Misunderstood and Underestimated


Depression, Hopelessness and Suicide Risk Among Patients Suffering From Epilepsy

In this pilot study a sample of 103 patients with a diagnosis of temporal lobe epilepsy were collected from 3 clinics. 26% of the patients had scores of 9 or greater on the Beck Hopelessness Scale suggesting they should be evaluated for suicidal inclinations. These patients were significantly older & had higher levels of depression […]

Suicide in Psychiatric Disorders

This book overviews & explores new areas of suicidal behaviours mainly in relation to psychiatric disorders. Chapters are also included on the effects of antidepressants on the suicide mortality of patients with major depression, attention deficit hyperactivity disorder, management of suicide risk in the psychiatric emergency department, suicide risk among epileptic patients, drug therapies, perspectives […]

Gender and Suicidality Prediction in Epilepsy

The current study was carried out to compare the accuracy of suicidal risk prediction in patients with epilepsy for each gender separately and as a group (males+females). The discriminant function analysis was performed to create an algorithm for suicidal risk classification for males and females separately and as a group. The main characteristics of epilepsy, […]

Depression and Suicide in Adolescents With Epilepsy

Depression & other disorders are underdiagnosed & undertreated in young people with epilepsy. Signs of depression are often dismissed as normal reactions, even though depression is a risk factor for suicide. A strong correlation between epilepsy & depression has been demonstrated in a variety of studies. At the time of initial diagnostic evaluation, a psychiatric […]

Unrecognized and Untreated: Preventing and Treating Depression in Patients With Epilepsy


Aggressiveness and Suicidal Attempts in Epilepsy

Published in “The Suicidal Process: Challenges for Treatment and Prevention”

Rate and Risk Factors For Suicide, Suicidal Ideation, and Suicide Attempts in Chronic Epilepsy

This article reviews the topic of suicide among individuals with epilepsy. Four specific areas are discussed: a) rates of suicide among individuals with epilepsy compared with the general population; b) risk factors for suicidal ideation & behavior; c) methods for assessing suicidal risk; d) clinical interventions & strategies to address suicidal risk in people with […]

Clinical Aspects of Epileptic Psychosis in Brazil

The authors investigated a series of patients with epileptic psychosis in Brazil & compared their findings with those of other authors, studying course & outcome for epilepsy & psychosis. Mean age of psychosis onset was 27.4 years, after a mean duration of epilepsy of 18.1 years, with predominance of schizophrenic presentations with interictal onset, frequent […]

Depression in Children and Adolescents With Epilepsy

This article summarizes the current data on the evaluation & treatment of depression in the general population of youths with epilepsy, with specific focus on issues related to comorbid epilepsy. Heightened risk of suicide in this population is discussed. (95 refs)