Resource Tag: EPILEPSY

Introduction Epilepsy is a neurological disease characterized by recurrent, unprovoked seizures and its impact on biological, cognitive, psychological, and social outcomes. An unmet need for finding effective treatment options exists. Identifying medical diagnoses present prior to a diagnosis of epilepsy is an important step in increasing our understanding of how people with epilepsy may respond […]

Objective Although increased mortality associated with epilepsy is well understood, data in patients after their first-ever seizure are limited. We aimed to assess mortality after a first-ever unprovoked seizure and identify causes of death (CODs) and risk factors. Methods A prospective cohort study was undertaken of patients with first-ever unprovoked seizure between 1999 and 2015 […]

Objectives: Little is known about self-harm in people with epilepsy, despite suicide being recognized as a leading cause of mortality in this population. This study aimed to investigate the characteristics of self-harm in people with epilepsy, and associated demographic and psychosocial factors. Methods: Patients presenting to hospital following self-harm between 1994 and 2008 were identified from the […]

Suicide prevention is a critical issue for young people. However, no large body of representative data on the risk of suicide attempts in school-aged patients with epilepsy in Taiwan or other developing countries is available. Patients aged ≤ 18 years who received a diagnosis of epilepsy between 2000 and 2012 were included in the epilepsy cohort (N = 9801). The […]

IMPORTANCE: People with epilepsy have a 5-fold increased risk of suicide. Less is known about attempted suicide and whether psychiatric disorders and antiepileptic drugs modify the risk of attempted suicide. OBJECTIVES: To estimate the magnitude of the association between attempted suicide and epilepsy by comparing a first suicide attempt and a second suicide attempt (hereafter […]

Highlights We examined suicide burden among people with epilepsy in 17 U.S. states (2003Ð2011). The estimated average annual suicide rate in those with epilepsy was 16.89/100,000 persons. Suicide risk in those with epilepsy was 22% higher than in the general population. Suicides occurred more often in residence, among those 40Ð49 years old, and by poisoning. […]

Highlights ¥ Evaluation the association among quality of life, affective disorders and suicidal risk. ¥ Affective somatoform dysphoric disorder and severity of the depressive disorder are related to suicidal risk. ¥ Lower quality of life is a predictor of an increase in suicidal risk. Contact us for a copy of this article, or view online […]

Objectives To estimate the magnitude of the association between attempted suicide and epilepsy by comparing a first suicide attempt and a second suicide attempt (hereafter referred to as a recurrent suicide attempt) among people before they received a diagnosis of epilepsy (case patients) with a first suicide attempt and a recurrent suicide attempt among people […]

In 2008, the U.S. Food and Drug Administration (FDA) issued an alert to health care professionals about an increased risk of suicide ideation and suicide behavior in people treated with antiepileptic drugs (AEDs). Since then, a number of retrospective cohort and case-control studies have been published that are trying to address this issue, but gathered […]

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The authors discuss the issue of suicide in epilepsy with special attention to antiepileptic drugs & the assessment of suicide in people with epilepsy. It has been suggested that early medical treatment with antiepileptic drugs might potentially reduce suicide risk in people with epilepsy, but it is of great importance that the choice of drugs […]

In this article, the association of epilepsy & antiepileptic drugs with psychiatric disease & suicidality are reviewed, perspective as to the significance & limitations of the American Food and Drug Administration’s findings are discussed, & some options for suicidality screening & their potential utility in clinical care are evaluated. (76 refs.) JA

This study investigated possible differences in suicide risk associated with different antiepileptic drugs. The use of antiepileptic drugs in the Danish population from 1997-2006 was determined by prescription claims. The risk of suicide associated with the use of antiepileptic drugs was estimated by case-crossover analyses, where each case serves as its own control during different […]

A meta-analysis was done to estimate the risk of suicide in people with epilepsy. Standardized mortality ratios with 95 percent confidence intervals were calculated for each cohort, for groups of cohorts, & for the total population. The overall standardized mortality ratio was 3.3 based on 190 observed suicides compared with 58.4 expected. This ratio was […]

This study determined if executive function & impulsivity are related to risk for suicide & suicide attempts in patients with temporal lobe epilepsy. 42 patiens were recruited. Mutliple regression analysis was carried out to examine predictive associations between clinical variables & Wisconsin Card Sorting Test measures. 24 patients had a score on the Risk for […]

The records of 43 deceased patients with well-classified epilepsy were analyzed, with special attention to cases of suicide. The subjects were compared with 1722 control patients who had showed definite subtypes of epilepsy. 6 patients died by suicide. There were no significant differences with regard to clinical variables except for psychotic episodes, which were more […]

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In this pilot study a sample of 103 patients with a diagnosis of temporal lobe epilepsy were collected from 3 clinics. 26% of the patients had scores of 9 or greater on the Beck Hopelessness Scale suggesting they should be evaluated for suicidal inclinations. These patients were significantly older & had higher levels of depression […]

This book overviews & explores new areas of suicidal behaviours mainly in relation to psychiatric disorders. Chapters are also included on the effects of antidepressants on the suicide mortality of patients with major depression, attention deficit hyperactivity disorder, management of suicide risk in the psychiatric emergency department, suicide risk among epileptic patients, drug therapies, perspectives […]

The current study was carried out to compare the accuracy of suicidal risk prediction in patients with epilepsy for each gender separately and as a group (males+females). The discriminant function analysis was performed to create an algorithm for suicidal risk classification for males and females separately and as a group. The main characteristics of epilepsy, […]

Depression & other disorders are underdiagnosed & undertreated in young people with epilepsy. Signs of depression are often dismissed as normal reactions, even though depression is a risk factor for suicide. A strong correlation between epilepsy & depression has been demonstrated in a variety of studies. At the time of initial diagnostic evaluation, a psychiatric […]

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Published in “The Suicidal Process: Challenges for Treatment and Prevention”