Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers

This study tested the hypothesis that tropomyosin-related kinase B expression is downregulated in suicide completers & that this downregulation is mediated by an epigenetic process. 39 French-Canadian men underwent screening using the HG-U133 plus 2 microarray chip. 9 frontal cortical regions & the cerebellum were assessed using a microarray screening approach for extreme expression differences […]

Domestic Homicide and Homicide-Suicide: the Older Offender

In a retrospective study of data from coroners’ files on domestic homicides involving individuals killed by an older spouse or family member over a 15-year period in Quebec, several specific offender & victim characteristics, & circumstances were identified. The homicide was frequently followed by the suicide of the perpetrator. Several victims had pre-existing medical illnesses. […]

Characterization of Impulsivity in Suicide Completers: Clinical, Behavioral and Psychosocial Dimensions

164 suicide cases with impulsivity scores based on the Barratt Impulsivity Scale were investigated. To examine the most extreme phenotypes, 100 suicide cases, representing subjects with scores above the seventieth percentile & below the thirtieth percentile were compared on clinical, behavioural, & psychosocial risk factors. The impulsive suicide cases were significantly younger, exhibited higher measures […]

Differences and Similarities in the Serotonergic Diathesis for Suicide Attempts and Mood Disorders: a 22-Year Longitudinal Gene-Environment Study

The final version of this paper was published in the August 15, 2010 issue of this journal.

Inter-Regional Variations in Men’s Attitudes, Suicide Rates and Sociodemographics in Quebec (Canada)

This study investigated, across the 17 regions of Quebec, men’s attitudes toward suicide, expressing pain, & help-seeking, as they are related to suicide rates & sociodemographic variables. Most correlations were nonsignificant. However, in regions with an above-average educational level & with higher divorce/separation rates, men had better attitudes towards expressing pain. Furthermore, in regions where […]

Firearms Regulation and Declining Rates of Male Suicide in Quebec

This study examined whether significant changes in method-specific male suicide rates occurred in Quebec after stronger firearms regulations were introduced in Canada in 1991; ascertained whether more stringent regulations influence firearms & total suicide trends among men; & determined whether different results are obtained according to the statistical methods used. The Joinpoint regression models suggest […]

Alcohol and Other Contextual Factors of Suicide in Four Aboriginal Communities of Quebec, Canada

This paper describes the psychosocial & behavioural characteristics of 30 consecutive adult suicides from 4 First Nations communities in Quebec. Psychological autopsies were done with family members. Suicide among this group was overrepresented by young single men. Alcohol intoxication at the time of death was reported for 22 cases in association with rapid acting out […]

Sexual Orientation and Gender Identity in Youth Suicide Victims: an Exploratory Study

55 child & adolescent suicide victims & 55 community controls in Quebec were assessed using semi-structured, proxy-based interviews & questionnaires regarding sexual orientation & gender issues, psychopathological diagnoses, & service use. No significant differences between the 2 groups were found regarding same-sex sexual orientation nor intimidation related to same-sex sexual orientation. Suicide victims with same-sex […]

Altered Expression of Lipid Metabolism and Immune Response Genes in the Frontal Cortex of Suicide Completers

Large-scale microarray gene expression analysis using the Affymetrix HG-U133 chipset was performed. The investigation focused on the expression profile of genes related to lipid metabolism & immune response in post-mortem brains from 22 male suicide victims & 13 male comparison subjects. Fatty acid desaturase, leptin receptor, phosphoinositide-3-kinase, & stearoyl-CoA desaturase were consistently down-regulated in all […]

Filicide: a Comparison by sex and Presence or Absence of Self-Destructive Behavior

This study identified sociodemographic, contextual, situational, & individual variables, as well as certain behavioural warning signs, associated with filicide as a function of sex of the aggressors & the presence or absence of self-destructive behaviours. The data included all cases of filicide in Quebec from January 1986-March 1994 against youth under the age of 18. […]

Use of a “Secure Room” and a Security Guard in the Management of the Violent, Aggressive or Suicidal Patient in a Rural Hospital: a 3-Year Audit

~

Predicting Suicide Attempts in Young Adults With Histories of Childhood Abuse

~

Alcohol Dependence-Related Increase of Glial Cell Density in the Anterior Cigulate Cortex of Suicide Completers

The authors investigated cell densities & sizes in BA24 among 13 suicide victims & 13 matched sudden-death controls. A 1-cubic centimetre tissue block from BA24a of the supracallosal ACC in 26 postmortem brain specimens were examined. Glial densities neuronal densities & soma sizes measured in BA24a did not differ significantly between controls & suicide victims. […]

L’epidemiologie du suicide au Quebec: Que savons-nous de la situation recente?

This report examines the epidemiology of suicide in Quebec. Statistics are provided on suicide by age, methods of suicide, the frequency of suicide in geographical regions, suicide in Quebec as compared to other regions of Canada, suicide in Quebec in comparison with other industrialized countries, & suicide attempts & suicide ideation.

Childhood Trajectories of Anxiousness and Disruptiveness as Predictors of Suicide Attempts

The association of childhood trajectories of anxiousness & disruptiveness with suicide attempts in early adulthood was investigated in a prospective cohort study of French-Canadian children. 1144 individuals participated in the study in early adulthood. In contrast to anxiousness trajectories, disruptiveness & joint trajectories made statistically significant contribtuions to suicide attempts. No support for mediation by […]

Maternal Filicide in Quebec

In an 8-year review (1991-1998) of all consecutive coroners’ files in Quebec, the authors identified 34 cases of victims who were killed by their mothers. There were 27 mothers in the sample, & 15 of them died by suicide after the filicide. A psychiatric motive was determined for more than 85% of the mothers, & […]

Les suicides dans les institutions carcerales

This French-language presentation discussed suicide in correctional institutions in Quebec, Canada.

Savoir parler aux jeunes de 15 a 19 ans au Quebec

In this French-language presentation, suicide among Quebec adolescents was discussed. Prevention strategies were described.

Current Psychiatric Morbidity, Aggression/Impulsivity, and Personality Dimensions in Child and Adolescent Suicide: a Case-Control Study

Psychiatric diagnoses, impulsive-aggressive & other personality traits were assessed in 55 child & adolescent suicide victims & 55 community controls using semi-structured proxy-based interviews & questionnaires. The most significant psychiatric risk factors associated with child & adolescent suicide were depressive disorders, substance/alcohol abuse disorder, & disruptive disorders. Additionally, suicide victims showed higher scores on lifetime […]

Broad and Narrow Personality Traits as Markers of One-Time and Repeated Suicide Attempts: a Population-Based Study

Qualitative & quantitative differences in broad & narrow personality traits between one-time & repeated suicide attempters were investigated in a longitudinal, population-based sample of young French Canadian adults using multivariate regression models. One broad (compulsivity) & one narrow (anxiousness) personality trait differentiated between individuals with histories of repeated & one-time suicide attempts. Affective instability & […]

Changes in Suicide Methods in Quebec Between 1987 and 2000: the Possible Impact of Bill C-17 Requiring Safe Storage of Firearms

This study presents the changes in the overall & firearm suicide rates for Quebec before & after Bill C-17, which was implemented to secure safe storage of firearms. It covers 20,009 suicide cases reported to the coroner’s office. Firearm suicide rates dropped among males & females, but the downward trends were not significant when compared […]

Guns in the Home: a High Risk

This article provides information for physicians on firearm deaths in Quebec. Risk factors for firearm homicide or suicide are listed as are questions to ask about the availability of guns when there is suspicion of suicide or homicide risk. There is brief discussion of intervention, confidentiality, & judicial rulings.

Adolescent Suicide in Quebec and Prior Utilization of Medical Services

~