In 2020, Cardinal Health Foundation (CHF) released a two-year national Zero Suicide Collaborative grant opportunity. CHF strategically partnered with the Zero Suicide Institute at Education Development Center (EDC) to provide funding, training, and expert support for health care systems to focus on the provision of safer suicide care. A total of 17 hospitals from across the United States participated in the Zero Suicide Collaborative from 2020 through 2022. The work captured in the following report directly touched more than 1.4 million unique patients in care settings across these systems. The purpose of this report is to describe the larger function and purpose of the project, key project outcomes and lessons learned, and implications and recommendations for future Zero Suicide Collaborative projects.