The incidence of depression in college students is increasing in recent years, which could lead to physical and mental diseases and negative academic outcomes. The causes of depression are related to both genetic and environmental factors. The main clinical therapy approaches of depression are medication and psychotherapy. In addition to clinical treatment, supports from educators are essential to students for intervention and prevention of depression in a school setting. Promoting students’ awareness of depression and abilities of stress management is beneficial for their mental health and academic outcomes.