This editorial discusses (1) strategic global developments in suicide prevention, (2) progress in suicide prevention at a global level, (3) the IASP-WHO Global Survey on Suicide Prevention, and (4) the challenges ahead. In terms of the content of a national suicide prevention program, the WHO global report recommends a systematic approach and summarizes typical components. Even though these components are supported by evidence, the strength and consistency of the evidence for some of the components/interventions in reducing suicide and attempted suicide or self-harm vary across different studies.