The coronavirus disease (COVID-19) has impacted not only physical health but also mental health and wellbeing globally. These impacts can be critically higher among marginalized individuals and populations like farmers in India. While most of them live in poor socioeconomic conditions, recent psychosocial challenges due to the COVID-19 lockdown had brought endless suffering in their lives. In this article, we describe a case of suicide of an Indian farmer amid COVID-19 lockdown, who had debts and could not find laborers during the lockdown leading to a helpless situation committing suicide. In India, nearly 16,500 farmers commit suicide each year, which can aggravate if psychosocial and economic challenges like COVID-19 continues to affect them. We recommend psychosocial interventions among vulnerable farmers alongside strengthening economic support and institutional measures alleviating socioeconomic challenges and minimizing disparities in social determinants of suicidal behavior to prevent suicide among Indian farmers amid the COVID-19 pandemic.