Year: 2016 Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry.(2016). Published online 29 January 2016. doi:10.1016/j.pnpbp.2016.01.013 SIEC No: 20160097

Highlights ¥ The childhood trauma produces epigenetic changes, which make victims vulnerable to adult trauma. ¥ The childhood trauma interacting with predisposing gene leads to psychopathology related to mental illness. ¥ The interaction between gene and childhood trauma influences the treatment refractoriness.