Proteomic Analysis of the CSF in Unmedicated Patients With Major Depressive Disorder Reveals Alterations in Suicide Attempters

This paper presents the first report on proteomic analysis of the cerebrospinal fluid in unmedicated suicide attempters & non-attempters with major depressive disorder. Two-dimensional gel electrophoresis revealed that suicide attempters differed from non-attempters in one protein with an approximate molecular weight of 33 kD & an isoelectric point of 5.2. Proteomic analysis of cerebrospinal fuild is a promising non hypothesis-driven screening method for the detection of new candidate genes in neurobiological suicide research. (8 refs.) JA