Abstract
The Treatment for Adolescents With Depression Study (TADS): Long-Term Effectiveness and Safety Outcomes
The TADS Team
The Treatment for Adolescents With Depression Study evaluates the effectiveness of fluoxtine hydrochloride therapy, cognitive-behavioural therapy, & their combination in adolescents with major depressive disorder. Randomized, controlled trials were conducted in 13 sites in the United States. 327 patients, aged 12-17 years, participated. Suicidal ideation decreased with treatment, but less so with fluoxetine therapy than with combination therapy or cognitive-behavioural therapy. Suicidal events were more common in patients receiving fluoxetine therapy (14.7%) than combination therapy (8.4%) or cognitive-behavioural therapy (6.3%). (57 refs.)