This paper examines the suicide rates of 23 cities and counties in Taiwan from 1983 to 2001. Wefound that a combination of economic and social variables can significantly account for the tremendous variations in suicide rates across TaiwanÕs cities and counties over the last two decades. The level of income per capita in a region appears as the most important predictor of suicide rates. However, some sociological correlates (such as divorce rate) which were less powerful in explaining suicide rate variations in the earlier study appear to exert more significant influence over suicide rates when eight more recent years of information are added, as in the current study. This study also uncovered several gender differences in the determination of regional suicide rates, such as the proportion of elderly population in the region, and the impacts of earthquake and unemployment. Furthermore, this study confirmed the linkages between natural disaster (earthquake) and suicide, between economic and social miseries (unemployment and divorce, respectively) and suicide, as well as those between demographics (aboriginal and elderly sub-population groups) and suicide. This may help to identify high-risk groups or areas where suicide prevention and intervention efforts should be concentrated on or directed to. Lastly, the local suicide crisis-intervention agencies are found to be significantly effective in reducing suicide rates of the community they serve.