Selective Serotonin Reuptake Inhibitors and Suicidality: a Guide for the Perplexed

In this review, the clinical significance of suicidal events in persons using antidepressants is discussed along with the factors that may increase or attenuate the risk, possible explanations for this phenomenon, the benefits & risks of antidepressants, the public health implications of a decline in the use of selective serotonin reuptake inhibitors, & recommendations for clinicians. (10 refs.)