The commentaries by Kalafat (2007) and Henriques (2007) propose new perspectives through which to view the treatment of “John” and highlight several issues related to the application of theory and science to the outpatient treatment of suicidal behaviors. In this response, I briefly address issues of clinical technique and theory, the therapeutic relationship, and misconceptions about transporting efficacious treatments into routine clinical practice. I argue that optimal clinical care uses a scientifically-informed, yet flexible, treatment approach tailored to the needs of the individual patient.