Year: 2007 Source: European Neuropsychopharmacology, v.17, no.1, (January 2007), p.12-15 SIEC No: 20070604

The relationship of CSF monoamine metabolites to lethality of suicidal acts in depressed subjects with comorbid alcoholism was studied. 16 high- & 16-low-lethality drug-free depressed suicide attempters with comorbid alcoholism were studied. CSF 5-HIAA levels were lower in high-lethality attempters compared to low-lethality attempters. There were no group differences in CSF homovanillic acid or 3-methoxy-4-hydroxyphenylglycol levels. Higher lethality of suicidal behaviour in depressed patients with alcoholism is concluded to be related to lower serotonergic activity. (31 refs.)