Year: 2006 Source: Biological Psychiatry, v.59, no.2, (January 15, 2006), p.114-120 SIEC No: 20070483

The 5-HTT gene-linked polymorphic region & intron 2 variants of this gene & their relationship to behavioural & clinical risk for factors for suicide were investigated in a sample of 106 depressed suicides & 152 depressed control subjects. A significant association of suicide completion with having at least one copy of the STin2 10 allele was found. No differences were found for the 5-HTTLPR variable number of tandem repeats. After controlling for risk factors, the STin2 variant remained a signficant predictor of suicide in major depression when jointly considered with a family history of suicide. (72 refs.)