Year: 2006 Source: PLoS, v.3, no.6, (June 2006), p.816-824 SIEC No: 20061068

The associations between suicide rates & dispensing of fluoxetine in the United States during 1960-2002 were examined. Suicide rates fluctuated between 12.2 & 13.7 per 100,000 for the entire population from the early 1960s until 1988. Since then, suicide rates have gradually declined; this decline is significantly associated with increased numbers of fluoxetine prescriptions dispensed. Mathematical modeling indicates that since the introduction of fluoxetine in 1988 through 2000, there has been a cumulative decrease in expected suicide mortality of 33,600 individuals. (48 refs.)