Year: 2003 Source: JAMA: Journal of the American Medical Association, v.290, no.11, (17 September 2003), p.1467-1473 SIEC No: 20041045

The authors compare risk of suicide attempt & suicide death during treatment with lithium with that during treatment with divalproex using a retrospective cohort study conducted at 2 large integrated health plans in California & Washington. In both plans, unadjusted rates were greater during treatment with divalproex than during treatment with lithium for emergency department suicide attempt, suicide attempt resulting in hospitalization, & suicide death. Risk for suicide death was 2.7 times higher during treatment with divalproex than with lithium. (46 refs)