Early age at Onset as a Risk Factor for Poor Outcome of Bipolar Disorder

The primary aim of this study was to investigate the effect of the age at onset of Bipolar Disorder (BP) on the clinical course of the illness. 320 subjects were studied using the SCID I. The authors found a significantly earlier age at onset in subjects with anxiety disorders & rapid cycling course. As well, subjects with early age at onset had more frequent suicidal ideation & attempts. The implications of these findings are discussed. (34 refs)