Year: 2002 Source: Bone Marrow Transplantation, v.29, no.5, (March 2002), p.373-377 SIEC No: 20030774

This article presents data from a randomized double-blind pilot study of rhIL-11 administered with cyclosporine/MTX prophylaxis after cytoxan/TBI conditioning & allogeneic stem cell transplantation for hematologic malignancies. The study was designed to assess safety with stopping rules for cardiac arrhythmias & mortality. All 13 patients received bone marrow stem cells. 1 of the 3 placebo recipients died by suicide. 5 of the 10 patients who were administered IL-11 died due to transplant-related toxicity. The results indicate that IL-11 cannot be recommended in future trials. (32 refs) (SC)