Abstract
Search for Viral Nucleic Acid Sequences in the Post Mortem Brains of Patients With Schizophrenia and Individuals who Have Committed Suicide
Carter G I~~Taylor G R~~Crow T J
Molecular hybridisation was used to screen several areas of post mortem brain for viral nucleic acids in 20 patients with schizophrenia, 23 individuals who were suspected of having committed suicide, & 21 control cases. Cloned probes were able to detect picogram levels of viral DNA & to quantify herpes simplex type 1 DNA from encephalitic brain, but no sequences hybridising to cytomegalovirus, varicella zoster virus, herpes simplex type I or JC or BK papovaviruses were detected in any of the experimental samples. These findings are discussed with reference to the viral hypothesis of the aetiology of psychiatric disease. (34 refs)