N-Acetylation and Serotonergic Measures in a Group of Psychiatric Patients

The purpose of this study was to explore the possibility of N-acetylation of dapsone reflecting serotonergic activity. The ratio of monoacetyldapsone/dapsone (MAD/DDS) in plasma, 5-HIAA in CSF, & imipramine-binding to platelets were investigated in a group of psychiatric patients, diagnosed according to the DSM-III as affective disorders, schizophrenia, & personality disorders. The N-acetylation of patients with a history of suicide attempt did not differ from those without. (26 refs)