This study examined the relationship among acculturative stress, depression, & suicidal ideation in a sample of Mexican immigrants. Multiple regression analyses revealed that acculturative stress significantly predicted depression & suicidal ideation & that family support, social support, religiosity, agreement with the decision to migrate, & expectations for the future were significant predictors of depression & suicidal ideation. The overall findings suggest that adult Mexican immigrants who experience elevated levels of acculturative stress may be at risk for experiencing critical levels of depression & suicidal ideation. The findings highlight the importance of using culturally relevant clinical methods in assessment & treatment. (65 refs.)