No Coding Variant of the Tryptophan Hydroxylase Gene Detected in Seasonal Affective Disorder, Obsessive-Compulsive Disorder, Anorexia Nervosa, and Alcoholism

The goal of this study was to evaluate the role of genetic variation in the coding sequence of tryptophan hydroxylase (TPH) in the pathogenesis of several psychiatric diseases in which altered serotonin function has been implicated. The results suggest that the coding sequence of the TPH gene does not contain abundant variants, and may not play a major role in vulnerability to several psychopathologies in which reduced serotonin turnover has been implicated.