Cholecystokinin in CSF From Depressed Patients: Possible Relations to Severity of Depression and Suicidal Behaviour

Levels of cholecystokinin peptides were measured in the CSF of 105 patients suffering from major depressive disorders. Relations between these levels & measures of depession, anxiety & suicidal behaviour were examined. Significant inverse correlations between cholecystokinen levels & certain depression & anxiety parameters. Patients who had made 1 or more suicide attempts tended to have higher levels of CSF cholecystokinen than those who had not. (28 refs.)