Year: 1997 Source: Annals of the New York Academy of Sciences, v.836, (December 29, 1997), p.233-252 SIEC No: 19980444

The biochemistry of the locus coeruleus (LC) of the brain was studied. The LC is the principal source of brain epinephrine, and there is evidence suggesting that neurons here are involved in manifestations of depression. The LC of suicide victims & controls were compared. Higher levels of tyrosine hydroxylase were found in the suicide victims. Ordway hypothesizes that suicide victims experience chronic activation of the LC, resulting in depletion of synaptic norepinephrine. (85 refs.)