Year: 1995 Source: Brain Research, v.675, no.1-2, (March 1995), p.157-164 SIEC No: 19970078

For this paper the authors examined the frontal cortices of 22 adult suicide victims compared with 22 age-matched sudden death controls. Results show that the proportion of high affinity, glycine displaceable (3H)CGP-39653 binding to glutamate receptors was reduced from 45 +/-5% in controls to 27 +/-6% in age and post-mortem interval-matched suicide victims.This data is the first demonstration supporting the hypothesis that glutamatergic dysfunction is involved in suicide and depression.