Year: 1994 Source: British Journal of Psychiatry, v.165, suppl.26, (December 1994), p.37-41 SIEC No: 19950168

This article reviews the literature on the clinical implications of a partial response to use of antidepressants in depression treatment. Patients who fail to reach premorbid levels of symptom remission are more vulnerable to relapse, work impairment, & suicide. Partial response may be one form of treatment resistance. Up to 20% of patients with major depression may be resistant to treatment with antidepressant medications. Future directions for research are noted. (27 Refs.)