This presentation provides a historical view on the Chronic Fatigue Syndrome (CFS) & notes that a literature review did not produce any references to suicide in CFS populations. 2 case summaries are provided as an aid in understanding the physical, psychological, & social impacts of CFS. They raise the question of CFS as a risk factor for suicide, identify it as a chronic & debilitating illness, & underscore the need to diagnose & aggressively treat the presence of affective syndromes.