Year: 1992 Source: Journal of Neurochemistry, v.59, no.1, (July 1992), p.73-80 SIEC No: 19920796

Neuropeptide Y (NPY) was measured in postmortem brain tissue from victims of suicide & from individuals dying a sudden natural or accidental death. Concentrations of NPY-immunoreactivity were significantly lower in postmortem frontal cortex & caudate nucleus from suicide victims compared with age-matched controls. The authors suggest there is a deficit in the brain NPY system leading to region-specific reductions in peptide concentrations in subjects who have a history of depression. (45 refs.)