Methylphenidate as a Treatment for Depression in Acquired Immunodeficiency Syndrome: an n-of-1 Trial

A double-blind, placebo-controlled n-of-1 trial was conducted to learn whether methylphenidate was an effective treatment for depression in a 54-year-old male outpatient with mild HIV dementia. Significant improvement in depression scores & mood self-assessment scores during therapy make a strong argument for this treatment. Treatment related improvements included improvement in sense of well-being, loss of suicidal ideation, improved interaction with peers, & diminished vegetative symptoms.