Year: 1989 Source: Drugs, v.37, no.2, (February 1989). p.123-140 SIEC No: 19890689

Lofepramine is a tricyclic antidepressant that is similar to imipramine & is extensively metabolised to desipramine. Its antidepressant activity appears to stem from the facilitation of noradrenergic neurotransmission, & possibly by the additional facilitation of serotonergic neurotransmission. Lofepramine has not been associated with adverse effects on cardiac function even in cases of attempted suicide by overdose.