Reviews work concerning human aggression, auto-aggression (Suicide), & the role of centre serotonin. THe impact of a “high-risk – low 5-HIAA group” upon clinical psychiatric practice is discussed. Damaging & self-destructive experience & behavior, & its biochemical aspects, are seen as a dysbalance syndrome causing well-defined vulnerability which, in turn becomes the basis of the psychopathology & psychodynamics of phenomena like aggression. 36 refs. (LH)