3 of 22 subjects in a study of neuroendocrine correlates of clinical change made serious suicide attempts, 2 of which were lethal. The suicidal subjects had significantly higher 24-hour urinary cortisol levels & significantly lower 24-hour urinary norepinephrine-to-epinephrine ratios than the non-suicidal patients had. The norepinephrine-to-epinephrine ratio finding is new. The clinical utility of neuroendicrine measures is enhanced by using a multihormonal profile.