Serum cholesterol level: A suitable biomarker of suicide and suicidal tendency

Suicide and suicidal tendencies have become a global public health problem. It is reported that more than 700 000 deaths are due to suicide. Suicide is the fourth leading cause of death among 15-29 year olds. Therefore, there are many studies conducted to find suitable solutions to prevent or reduce suicidal deaths. Many epidemiological surveys are conducted to delineate and discuss the present status of suicide and human behavior.  Apart from the routine surveys it has been postulated there is a link between serum cholesterol level and suicide. Cholesterol being an important constituent of plasma membrane its concentration will influence membrane  structure and its function. It has been shown that in patients who have attempted or committed suicide the serum cholesterol level is low compared to the normal population. In this short review the role of cholesterol in suicide is analyzed  taking into account its role in serotonin receptor and its function.