This systematic review analyses research that introduces commercial design applications that could be adopted for suicide prevention in homes. Furthermore, this literature review captures social, spatial and biophilic design methods to improve wellness in homes using environmental design psychology. Safety and human wellness frame this spatial design research that examines means and access restriction to improve home safety and prevent suicides. Suicide is a growing phenomenon that deserves specific attention to how environments can impact or restrict events. There is a substantial evidence base to evaluate suicide prevention methods used in high-risk environments of health and healing environments, workplaces and incarceration facilities. This review outlines design methods using spatial arrangement and material choices to improve human wellness in homes. The effects of biochemical reactions, such as those studied in toxicology, and stress are considered in this research to suggest material choices and applications in design to improve mental health in homes. Spatial designs for suicide prevention can guide various prevention measures, such as adopting means and access restriction and environmental design methods for wellness and considering impacts during lockdown periods. Environmental design psychology research supplies evidence for improved spatial arrangements in homes, with evidence showing that design applications can restore and improve mental health. This systematic review shows evidence for planning methods to prevent suicides considering both means and access restriction with considerable biochemical impacts from design. Design methods discovered by this systematic review will be considered for future studies and used within economic modelling to demonstrate design guidelines that improve wellbeing and support existing suicide prevention methods for Australian homes.