Objective Negative social interactions are known to contribute to the development of suicide ideation. However, it is unclear how this risk factor interacts with other predisposing risk factors. The purpose of this study was to determine how social and neuropsychological factors interact as a prospective predictor of the emergence of suicide ideation in adolescents. Method Data were collected from adolescents (M age = 13.12, SD = 1.48) over 3 years as part of a larger study. Participants completed the MINI-Kid and Youth Self-Report, which were used to assess for suicidality. Negative social interactions were operationalized as the Social Problems scale of the YSR. Additionally, adolescents completed a neuropsychological battery at each wave of data collection. Results Logistic moderation analyses demonstrated a significant interaction between task switching and endorsement of negative social interactions in the prediction of suicide ideation one year later, Wald χ2(1) = 4.94, OR = 0.90, p < .05. Distractibility was a significant predictor, Wald χ2(1) = 5.52, OR = 3.45, p < .05, but it did not demonstrate an interaction effect. Perseveration failed to reach statistical significance independently and in the interaction. Conclusions The results indicate that certain neuropsychological characteristics can aid in predicting which adolescents will develop suicide ideation in the presence of negative social interactions, which may have significant clinical implications.