In the COVID 19 epidemic, almost every Human Being on Earth is suffering from some other mental health problem whether it is due to Economical crises, loss of a job, domestic violence, someone close that is infected by Coronavirus, or the recent death of loved ones due to Corona Virus. The pain of the loss of attachment or incapability to fulfill the hopes and desires of self or others leads to suicidal thoughts and self-destruction tendencies. It is documented by the Four Noble Truths that self destruction is a type of experience that starts by wanting/sticking. neither we can escape from the “chakra of suffering” nor the suffering of suicide. This review article will also look at the psychosocial factors precipitating suicidal tendencies and the relative literature regarding the prevention of the same. Several researchers have indicated the Buddhism principle on general aspects such as only four noble truths, concentration, and/or meditation. From the present study, the Buddhist principles are divided into the following areas: 1) Buddhism toward suicide, 2) The suffering in suicide, 3) Detachment from Clinging, 4) Four noble truths, 5) Eightfold paths in the prevention of Suicide, 6) Role of concentration in the abandonment of Suicidal thoughts, 7) Practice of meditation and mindfulness, 8) Psychological and Sociological cause behind suicide.