The 2022 National Veteran Suicide Prevention Annual Report analyzes Veteran suicide data from 2001-2020. Containing the most comprehensive set of data about Veteran suicide mortality to date, the report is the first to evaluate Veteran suicide during the initial period of the COVID-19 pandemic. Key report findings In 2020, there were 6,146 Veteran suicide deaths, which was 343 fewer than in 2019. The unadjusted rate of suicide in 2020 among U.S. Veterans was 31.7 per 100,000. Over the period from 2001 to 2020, age- and sex-adjusted suicide rates for Veterans peaked in 2018 and then fell in 2019 and 2020. From 2018 to 2020, age- and sex-adjusted suicide rates for Veterans fell by 9.7%. Among non-Veteran U.S. adults, age- and sex-adjusted suicide rates also peaked in 2018 and fell in 2019 and 2020. From 2018 to 2020, age- and sex-adjusted suicide rates for non-Veteran adults fell by 5.5%. From 2019 to 2020, the age- and sex-adjusted suicide rate for Veterans fell by 4.8%, while for non-Veteran U.S. adults the adjusted rate fell by 3.6%. From 2019 to 2020, among Veteran men, the age-adjusted suicide rate fell by 0.7%, and among Veteran women the age-adjusted suicide rate fell by 14.1%. By comparison, among non-Veteran U.S. men, the age-adjusted rate fell by 2.1%, and among non-Veteran women the age-adjusted rate fell by 8.4%. Comparisons of trends in Veteran suicide and COVID-19 mortality over the course of 2020 and across Veteran demographic and clinical subgroups did not indicate an impact of the COVID-19 pandemic on Veteran suicide mortality.