Capturing the experiences of nearly 34,000 LGBTQ youth ages 13-24 across the United States, with 45% of respondents being LGBTQ youth of color and 48% being transgender or nonbinary, our fourth annual national survey is one of the most diverse surveys of LGBTQ youth ever conducted. These data provide critical insights into some of the unique suicide risk factors faced by LGBTQ youth, top barriers to mental health care, and the negative impacts of COVID-19 and relentless anti-transgender legislation. This research also highlights several ways in which we can all support the LGBTQ young people in our lives — and help prevent suicide.