Abstract

A Review of Prospective Studies of Biologic Predictors of Suicidal Behavior in Mood Disorders

Mann J J~~Currier D

Year: 2007 Source: Archives of Suicide Research, v.11, no.1, (2007), p.3-16 SIEC No: 20080334

The authors review prospective studies of suicidal behaviour & serotonergic, noradrenergic, dopaminergic, & hypothalamic-pituitary-adrenocortical axis function in mood disorders. The most promising biological predictors are low CSF 5-HIAA and HPA axis dysfunction as demonstrated by dexamethasone non-suppression that are each associated with about 4.5 fold greater risk of suicide. (98 refs.)