The 92 suicides investigated by the medical examiner’s office in Rhode Island between 1975 and 1982, in which either tranquilizers or antidepressant drugs were present in the body fluids or tissues of the deceased, were studied. More antidepressant than tranquilizer suicide victims had a history of psychiatric hospitalization and had previously attempted or spoken about suicide. Findings indicate that this group also took more time and effort in both contemplating and planning their suicides.