Association between buprenorphine for opioid use disorder and mortality risk

Introduction: Veterans with opioid use disorder have an increased risk of suicide and overdose compared with the general population. Buprenorphine, a U.S. Food and Drug Administration–approved medication to treat opioid use disorder, has shown benefits, including decreased risk of illicit drug use and overdose. This study assesses the mortality outcomes with buprenorphine pharmacotherapy among Veterans […]

The impact of trauma, substance abuse, and psychiatric illness on suicidal and self-harm behaviours in a cohort of migrant detainees: An observational, prospective study

Background: According to the WHO, detainees attempt suicide ten times more than the general population. Aims: To investigate the impact of migration trauma on Suicidal and Self-Harm Behaviours (SSHB) of migrants in jail and to explore how substance use and other psychiatric features affect this relationship. Methods: Prospective cohort study, conducted at the ‘Sant’Anna’ jail […]

Exploring the genetic overlap of suicide-related behaviors and substance use disorders

Suicide-related behaviors are heterogeneous and transdiagnostic, and may demonstrate varying levels of genetic overlap with different substance use disorders (SUDs). We used linkage disequilibrium score regression, genomic structural equation models, and Mendelian randomization to examine the genetic relationships between several SUDs and suicide-related behaviors. Our analyses incorporated summary statistics from the largest genome-wide association studies […]

Differential predictors of suicidal ideation and suicide attempts: Internalizing disorders and substance use in a clinical sample of adolescents

Objective: Dually diagnosed adolescents are a high-risk population for experiencing suicidal thoughts and behavior. Given that research suggests risk factors for suicidal ideation and suicide attempts may be different, this study examined whether internalizing disorder severity, frequency of substance use, and the interaction between them differentiated adolescents who attempted suicide from those who ideated. Methods: […]

Comparative risk of suicide by specific substance use disorders: A national cohort study

Substance use disorders (SUDs) are important risk factors for suicide, yet little is known about how suicide risks vary by specific SUDs. We examined these risks for the first time in a large general population to facilitate comparisons across SUDs. A national cohort study was conducted of all 6,947,191 adults in Sweden. SUDs (opioid, sedative/hypnotic, hallucinogen, cannabis, amphetamine, […]

Impulsivity and impulsivity-related endophenotypes in suicidal patients with substance use disorders: An exploratory study

Suicidal behavior (SB) is a major problem in patients with substance use disorders (SUDs). However, little is known about specific SB risk factors in this population, and pathogenetic hypotheses are difficult to disentangle. This study investigated some SB and SUD-related endophenotypes, such as impulsivity, aggression, trait anger, and risk-taking behaviors (RTBs), in forty-eight patients with […]

Childhood trauma and the severity of past suicide attempts in outpatients with cocaine use disorders

Suicide attempts have been associated with both cocaine use disorder (CocUD) and childhood trauma. We investigated how childhood trauma is an independent risk factor for serious and recurrent suicide attempts in CocUD. Method: 298 outpatients (23% women) with CocUD underwent standardized assessments of substance dependence (Diagnostic and Statistical Manual—mental disorders, fourth edition, text revised), impulsiveness, […]

Mental health, substance use, and suicidal ideation during a prolonged COVID-19-related lockdown in a region with low SARS-CoV-2 prevalence

The coronavirus disease 2019 (COVID-19) pandemic has been associated with mental health consequences due to direct (i.e., SARS-CoV-2 infection, potentially due to neuronal or astrocytic infection, microvascular, or inflammatory mechanisms) and indirect (i.e., social and economic impacts of COVID-19 prevention measures) effects. Investigation of mental health in a region with one of the longest lockdowns […]

Substance use, mental health and suicide among Inuit in Canada

Created in partnership with Inuit Tapiriit Kanatami, the national organization representing Inuit across Canada, this report in short summarizes statistics on substance use and mental health among Inuit. It identifies risk factors for suicide, including community distress, mental health conditions, substance use and socioeconomic inequities. Statistics on alcohol, cannabis and other substance use are also […]

Relationships between non-suicidal self-injury and other maladaptive behaviors: Beyond difficulties in emotion regulation

Non-suicidal self-injury (NSSI) co-occurs with both other maladaptive behaviors (e.g., aggression) and emotion dysregulation. However, the extent to which these maladaptive behaviors are linked to NSSI independent of emotion dysregulation is unclear. The present study examined relationships between NSSI and six other maladaptive behaviors among university undergraduates. When controlling for demographic variables, emotion dysregulation, and […]

A qualitative exploration of young people’s experiences of attempted suicide in the context of alcohol and substance abuse.

The aim of this study was to explore young people’s experiences of the role and the processes underpinning the use of alcohol and/or other substances in attempts to end their life. Seven young people, aged 16–25 years old, were interviewed using in-depth, semi-structured interviews. Interpretative Phenomenological Analysis was used to analyse these interviews and develop […]

Factors associated with the time to transition from suicidal ideation to suicide plans and attempts in the Australian general population

Background. Suicide plans and attempts rarely occur without prior suicidal ideation but are hard to predict. Early intervention efforts need to focus on subgroups of the population who are more likely to transition from ideation to suicidal plans and attempts. The current study utilised data from a large nationally representative sample to investigate the time […]

Mental health, substance abuse, prison victimization and suicide attempts amongst incarcerated women

Worldwide, incarcerated women are known to suffer adverse experiences that might increase the risk of suicide attempts during incarceration. The present investigation examines the prevalence of suicide attempts amongst incarcerated women in Spain and the factors associated with this. Between January and March of 2017 a total of 174 women, enrolled from two prisons in […]

Substance use and suicide outcomes among self-injured trauma patients

Background Research indicates alcohol (AUD) or substance (SUD) use disorders and acute alcohol or drug use serve as risk factors for suicidal behaviors and death both distally and proximally to a suicidal event. However, limited research has investigated these relationships among medically serious suicide attempters at the time of injury without relying on cohorts of […]

Prevalence and severity of psychiatric disorders and suicidal behavior in service members and veterans with and without traumatic brain injury: Systematic review

Objectives: Assess prevalence and severity of posttraumatic stress disorder, suicidal behavior, and depressive, substance use, and anxiety disorders in US service members or Veterans with and without a deployment-related mild traumatic brain injury (TBI) (mTBI). Design: Systematic review using multiple databases (January 2000 to October 2017). We included national or geographically diverse samples. Main Measure: Prevalence and […]

Relationship between suicide attempt history and borderline personality disorder, aggression, impulsivity, and self-mutilative behavior among male inpatients with substance use disorder

Objective: The purpose of this study was to evaluate the relationship between lifetime history of suicide attempt (HSA) and borderline personality disorder (BPD), aggression, impulsivity, and selfmutilative behavior (SMB) in a sample of male inpatients with substance use disorder (SUD). Method: The sample included 132 male inpatients with alcohol or opioid use disorder. The participants […]

Pilot study of mental health and substance use of detained youths in Ontario, Canada

Detained youth display substantive mental health and substance use problems. However, Canadian information is limited. The purpose of this study was (1) to assess mental health and substance use problems of youth in residential detention/custody facilities in Ontario, Canada, at intake, using the interRAI Youth Justice in Custodial Facilities (YJCF), and (2) to explore the […]

The impact of COVID-19 on mental, neurological and substance use services: Results of a rapid assessment

This report of a survey completed by 130 countries during the period June-August 2020 provides information about the extent of disruption to mental, neurological and substance use services due to COVID-19, the types of services that have been disrupted, and how countries are adapting to overcome these challenges.

Suicide safer care in behavioral health settings: A comparative analysis of perceptions, training completion, and practice between mental health and substance use disorder treatment providers

Background Despite prevention and treatment efforts, opioid overdose deaths continue to rise in the United States and totaled 46,802 in 2018. This public health crisis is closely linked with suicide, with those who misuse opioids at six times the risk of death by suicide. Suicide prevention in substance use disorder (SUD) treatment may be a […]

The moderating role of psychological inflexibility in the relationship between minority stress, substance misuse, and suicidality in LGB+ adolescents

Minority stress has been posited as a framework to explain the health disparities seen in sexual minority youth, including lesbian, gay, bisexual (LGB+) youth. In the present study, psychological inflexibility was investigated as a moderator in the relationship between minority stress and two harmful youth outcomes: substance misuse and suicidality. Analyses showed significant interactions indicating […]

A naturalistic study of youth referred to a tertiary care facility for acute hypomanic or manic episode

Background: Bipolar Disorders (BD) in youth are a heterogeneous condition with different phenomenology, patterns of comorbidity and outcomes. Our aim was to explore the effects of gender; age at onset (prepubertal- vs. adolescent-onset) of BD; and elements associated with attention deficit hyperactivity disorder (ADHD) and Substance Use Disorder (SUD) comorbidities, severe suicidal ideation or attempts, and […]

Individual contribution of youth antisocial symptoms to suicide behavior in adults with substance use disorders

This study assesses the individual contribution of youth symptoms of antisocial personality disorder (before the age of 15) in past-month suicidal behavior in adults with substance use disorders. Youth antisocial symptoms and suicidal behavior were assessed using the Mini International Neuropsychiatric Interview. Indicators of youth antisocial symptoms were significantly associated with suicide outcomes; lack of […]

Suicide attempt and associated factors among adolescents in five southeast Asian countries in 2015

Background: Suicide is a major cause of death among adolescents. Aims: The study aimed to report on the prevalence and correlates of suicide attempt among in-school adolescents in five Southeast Asian countries. Method: Cross-sectional data from the 2015 Global School-Based Student Health Survey (GSHS) included 33,004 middle-school children (mean age = 14.3 years, SD = 1.6) that were representative of all students […]