Neurobiological Underpinnings of Suicidal Behavior: Integrating Data From Clinical and Biological Studies

Published English-language literature was reviewed to identify evidence supporting a multi-dimensional model of putative causal pathways for suicidal behaviour. There is evidence that clinical, neurochemical, neuroendocrine, neurocognitive, & neurophysiological contributory factors may be useful as intermediate phenotypes in describing putative causal pathways from genetics & early-life adversity to suicidal acts. It is concluded that determining[…]

Trauma, Attempted Suicide, and Morning Cortisol in a Community Sample of Adolescents

This sutdy explored the association between morning cortisol, trauma, & suicide attempts or ideation among young people. In a community-based sample of 501 15-year-olds, using data from a DSM-IV-compatible interview on suicidal behaviour/ideation, trauma, & morning cortisol, the authors found no association between these factors & morning cortisol. A significant gender interaction was found for[…]

Gonadal Axis Hormones in Psychiatric Male Patients After a Suicide Attempt

Plasma levels of testosterone, luteinizing hormone, & follicle stimulating hormone were estimated in 80 male subjects after a suicide attempt & in whom a psychiatric assessment was done during their hospitalization. Suicide intent was evaluated in 72 subjects. A group of 56 healthy males served as controls. As a group, attempters showed significantly lower testosterone[…]

A Pilot Study on a Gene-Hormone Interaction in Female Suicide Attempts

In a first set of analyses, an association between menses & suicide attempts was replicated. According to the polymorphism of the serotonin transporter promoter area, subjects could be classified as S individuals (s/s or s/l) or L individuals (l/l). This third set of analyses tested for an interaction between the same polymorphism & low hormonal[…]

Suicidal Behavior in Young Women


Serum Cholesterol and Leptin Levels in Patients With Borderline Personality Disorder


The Possible Factors Affecting Suicide Attempts in the Different Phases of the Menstrual Cycle

This study investigated whether there is a relationship between the menstrual cycle & suicide attempts, & determined the factors affecting suicide attempts in different phases of the menstrual cycle. The study sample included 52 women admitted to an emergency room because of a suicide attempt. The incidence of suicide attempts in menstrual follicular phase was[…]

Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-releasing Hormone Receptors and GABA Receptor Subunits in Frontal Cortical Brain Region


Lack of Effect of HPA Axis Hyperactivity on Hormonal Responses to D-Flenfluramine in Major Depressed Patients: Implications for Pathogenesis of Suicidal Behaviour

The aim of this study was to investigate whether hypothalamic-pituitary-adrenal (HPA) axis hyperactivity is associated with 5-HT dysfunction in depressed patients, especially in those with suicidal behavior. Patients with a history of suicide attempt, when compared with patients without such a history, showed lower hormonal responses to d-fenfluarmine but comparable basal & post-desamethasone suppression test[…]

Association Between the Menses and Suicide Attempts: a Replication Study

Based on their own earlier findings, the authors tested their hypothesis that the proportion of suicide attempters during the menses is significantly higher than the expected probability in the general population using a replication naturalistic study of 120 fertile adult female suicide attempters with regular menstruation cycles during a 1-year period in the emergency room[…]