Associations between genetic risk for adult suicide attempt and suicidal behaviors in young children in the US

Importance  Suicide rates have been increasing among youth in the US. While the heritability of suicide risk is well established, there is limited understanding of how genetic risk is associated with suicidal thoughts and behaviors in young children. Objective  To examine whether genetic susceptibility to suicide attempts (SAs) is associated with suicidal thoughts and behaviors in children. […]

Exploring the genetic overlap of suicide-related behaviors and substance use disorders

Suicide-related behaviors are heterogeneous and transdiagnostic, and may demonstrate varying levels of genetic overlap with different substance use disorders (SUDs). We used linkage disequilibrium score regression, genomic structural equation models, and Mendelian randomization to examine the genetic relationships between several SUDs and suicide-related behaviors. Our analyses incorporated summary statistics from the largest genome-wide association studies […]

Dissecting the shared genetic architecture o suicide attempt psychiatric disorders, and known risk factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of […]

Assessment of suicide attempt and death in bipolar affective disorder: A combined clinical and genetic approach

Bipolar disorder (BP) suicide death rates are 10–30 times greater than the general population, likely arising from environmental and genetic risk factors. Though suicidal behavior in BP has been investigated, studies have not addressed combined clinical and genetic factors specific to suicide death. To address this gap, a large, harmonized BP cohort was assessed to […]

Rare protein-coding variants implicate genes involved in risk of suicide death

Identification of genetic factors leading to increased risk of suicide death is critical to combat rising suicide rates, however, only a fraction of the genetic variation influencing risk has been accounted for. To address this limitation, we conducted the first comprehensive analysis of rare genetic variation in suicide death leveraging the largest suicide death biobank, […]

Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide

Suicide accounts for nearly 800,000 deaths per year worldwide with rates of both deaths and attempts rising. Family studies have estimated substantial heritability of suicidal behavior; however, collecting the sample sizes necessary for successful genetic studies has remained a challenge. We utilized two different approaches in independent datasets to characterize the contribution of common genetic […]

Contribution of genes and environment to the longitudinal association between childhood impulsive-aggression and suicidality in adolescence

Background Population‐based and family studies showed that impulsive‐aggression predicts suicidality; however, the underlying etiological nature of this association is poorly understood. The objective was to determine the contribution of genes and environment to the association between childhood impulsive‐aggression and serious suicidal ideation/attempt in young adulthood. Methods N = 862 twins (435 families) from the Quebec Newborn Twin […]

An examination of genes, stress and suicidal behavior in two First Nations communities: The roles of the brain-derived neurotropic factor gene

Suicide claims over 800,000 lives each year worldwide. Suicide rates in indigenous populations in Canada are about double that of the national average, making it a serious public health issue. Numerous factors are involved in suicide risk, including genetic factors, as well as various psychosocial stressors, such as historical experience with the Indian Residential School […]

An examination of genes, stress and suicidal behavior in two First Nations communities: The role of the brain-derived neurotropic factor gene

Suicide claims over 800,000 lives each year worldwide. Suicide rates in indigenous populations in Canada are about double that of the national average, making it a serious public health issue. Numerous factors are involved in suicide risk, including genetic factors, as well as various psychosocial stressors, such as historical experience with the Indian Residential School […]

Genetic and environmental pathways to suicidal behavior: Reflections of a genetic epidemiologist.

This paper presents a tentative typology of genetic and environmental pathways to suicidal behavior. Ten pathways are proposed and briefly illustrated: (i) direct effects from psychiatric disorders; (ii) direct effects from personality; (iii) direct effects of early adversity; (iv) direct effects of current adversity; (v) indirect effects of genes on selection into adversity (gene-environment correlation); […]

Genetic influences on suicide and nonfatal suicidal behavior: Twin study findings.

It has been well established that suicidal behavior is familial. Twin studies provide a unique opportunity to distinguish genetic effects from other familial influences. Consistent with findings from previous twin studies, including case series and selected samples, data from the population-based Swedish Twin Registry clearly demonstrate the importance of genetic influences on suicide. Twin studies […]

Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression.

Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to […]

Precision medicine for suicidality: From universality to subtypes and personalization.

Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. […]

A genetic risk factor for major depression and suicidal ideation is mitigated by physical activity.

Highlights •This study demonstrates that physical activity diminishes risk of major depressive disorder (MDD) and suicidal ideation (SI) imposed by a genetic predisposition. •Carriers of the mineralocorticoid receptor genetic variant −2C/G C allele were nearly twice as likely to meet criteria for probable MDD and three times as likely to report SI compared with noncarriers […]

Anorexia nervosa, major depression, and suicide attempts: Shared genetic factors.

The extent to which genetic and environmental factors influenced anorexia nervosa (AN), major depressive disorder (MDD), and suicide attempts (SA) were evaluated. Participants were 6,899 women from the Swedish Twin Study of Adults: Genes and Environment. A Cholesky decomposition assessed independent and overlapping genetic and environmental contributions to AN, MDD, and SA. Genetic factors accounted […]

Tryptophan hydroxylase gene 218A/C polymorphism is not associated with depressed suicide.

Abnormalities in functioning of the central serotonergic system are believed to be involved in the pathogenesis of depressive illness and suicidal behaviour. Recently, polymorphism in the tryptophan hydroxylase (TPH) gene has been studied for association with aggression, anger-related traits and suicidal behaviour, but the results are inconclusive. The present investigation was to determine whether there […]

Gene environment interaction studies in depression and suicidal behavior: An update.

Highlights: Evidence supports both heritable and environmental influences in depression and suicidal behavior risk. GeneÐenvironment interaction (G _ E) studies may be useful to investigate the impact of both sources of risk. So far, within this context, only few results have been obtained in both depression and suicidal behavior, though some genes seems reliably moderating […]

Epigenetic programming by maternal behavior.

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Safeguarding clinical translation of pluripotent stem cells with suicide genes.

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Analysis of CpG SNPs in 34 genes: association test with suicide attempt in schizophrenia.

Background: Suicide is the act of intentionally causing one’s own death. The lifetime suicide risk in schizophrenia is 4.9% and 20% to 50% of patients with SCZ will attempt suicide during their life. The other risk factors for suicidal behavior in schizophrenia include prior history of suicide attempts, active psychosis, depression and substance abuse. To […]

A kin selection model of suicide risk.

Suicide has rarely been considered from an evolutionary perspective, likely because it appears prototypically maladaptive, and certainly appears to have no adaptive function. The current theory proffers a potential adaptive function of suicide: it might constitute a nepotistic response to pronounced resource scarcity. If this is so, conditions which maximize the adaptiveness of nepotistic behaviors […]

Genome-wide methylation changes in the brains of suicide completers.

Objective: Gene expression changes have been reported in the brains of suicide completers. More recently, differences in promoter DNA methylation between suicide completers and comparison subjects in specific genes have been associated with these changes in gene expression patterns, implicating DNA methylation alterations as a plausible component of the pathophysiology of suicide. The authors used […]

Association of FKBP5 Polymorphisms With Suicidal Events in the Treatment of Resistant Depression in Adolescents (TORDIA) Study

The relationship between candidate genes & 2 clinical outcomes, symptomatic improvement & the occurrence of suicidal events, was assessed in a sample of treatment-resistant depressed adolescents. Depressed adolescents were genotyped with respect to 21 polymorphisms on 12 genes that have a reported association with depression, treatment response, or suicidal events. No response was observed between […]