Evaluation of common prescription analgesics and adjuvant analgesics as markers of suicide risk: A longitudinal population-based study in England

Background: Analgesics prescriptions may provide a marker for identifying individuals at higher risk of suicide. In particular, awareness of which analgesics are implicated may help clinicians assess and modify risk. Method: A case–control study in England using the Clinical Practice Research Datalink (for primary care records) linked with hospital and national mortality electronic registries. We […]

The use of analgesics for intentional self-poisoning: Trends in U.S. poison center data

In the U.S., intentional self-poisonings with analgesics that are available without a prescription increased from 2000 to 2018. Given concerns regarding mental health outcomes during the COVID-19 pandemic, we examined and compared trends in pediatric and adult intentional self-poisoning with acetaminophen, aspirin, ibuprofen, and naproxen from 2016 to 2021 using the National Poison Data System […]

Nonmedical use of prescription opioids, psychological distress, and suicidality among adolescents

Purpose The present study examined associations between nonmedical use of prescription opioids and serious psychological distress, suicidal ideation, and suicide attempts, and tested whether age and sex moderate these relationships. Methods Data on 5582 adolescents were obtained from a representative province-wide survey of students in grades 7 through 12 (mean age: 15.3 years) across Ontario, Canada. […]

Effects of intravenous ketamine in a patient with post-treatment Lyme disease syndrome.

Post-treatment Lyme disease syndrome (PTLDS) is a pain disorder for which there remains no gold standard treatment option. Here, we report a case of PTLDS in a female patient whose pain was refractory to treatment options such as radiofrequency ablation, vitamin infusion therapy, opioid analgesics, and other pharmacotherapies. The patient commenced an experimental intravenous ketamine […]

Frequency of prescription opioid misuse and suicidal ideation, planning, and attempts.

The goal of this study was to examine the relationship between past-year frequency of prescription opioid misuse and past-year suicidal ideation, suicide planning, and suicide attempts. Secondary data analyses were conducted using data from 41,053 participants of the 2014 National Survey of Drug Use and Health. Past-year frequency of prescription opioid misuse was grouped into […]

Co-Proxamol Withdrawal has Reduced Suicide From Drugs in Scotland

This study examined what effect the withdrawal of co-proxamol from the United Kingdom market had on mortality from poisoning in Scotland. A retrospective, observational study of mortality due to poisoning by single agents was done for the period 2000-2006. A significant reduction in the proportion of poisoning deaths due to co-proxamol was observed following legislation. […]

A Hospital-Based Study on Trends in Deliberate Self-Harm in Children and Adolescents

In this letter to the editor, the authors discuss children & adolescents who were admitted to the Teaching Hospital in Karapitiya (Sri Lanks) following deliberate self-harm. Admissions for deliberate self-harm increased by 91% from 2001 to 2007 with girls accounting for most of this increase. Admissions for deliberate self-harm increased consistently with age. Admissions after […]

Increased use of Medicinal Drugs in Self-Harm in Urban Areas in Sri Lanka

This study described substances used in overdose & the characteristics of patients admitted with medicinal drug overdose in an urban tertiary care hospital in Colombo. A descriptive study of 191 patients admitted with intentional self-poisoning was carried out. Medicinal drugs were the most common substance used in overdose. Those who used medicinal drugs were mainly […]

Acetaminophen Overdose in Jamaica


Effect of Withdrawal of Co-Proxamol on Prescribing and Deaths From Drug Poisoning in England and Wales: Time Series Analysis

This study assessed the effect of the UK Committee on Safety of Medicines’ announcement in January 2005 of withdrawal of co-proxamol on analgesic prescribing & poisoning mortality. An interrupted time series analysis for 1998-2007 was done. A steep reduction in prescribing of co-proxamol occurred in the post-intervention period, 2005-2007, such that the number of prescriptions […]

The Epidemiology of Self-Poisoning in the UK


Legislation Restricting Paracetamol Sales and Patterns of Self-Harm and Death From Paracetamol-Containing Preparations in Scotland


A Multicentre Study of Coproxamol Poisoning Suicides Based on Coroners’ Records in England

Inquest records in 24 coroners’ jurisdictions in England on deaths between 2000-2001 which received a verdict of etiher suicide or undetermined cause (with a high or moderate probability of suicide) were examined. 123 coproxamol poisoning suicides were identified. Alcohol was involved in 58.5% of cases. Younger people were more likely to have consumed alcohol & […]

Does Restricting Pack Size of Parcetamol (Acetaminophen) Reduce Suicides?

Refer to SIEC # 2007-0661 for the article by Morgan et al

How has Legislation Restricting Paracetamol Pack Size Affected Patterns of Deprivation Related Inequalities in Self-Harm in Scotland

Objective To describe how changes in legislation to control sales and thus restrict the general availability of paracetamol have affected deprivation-related inequalities in deliberate self-harm associated with the drug in Scotland. Design and setting A descriptive analysis of routine death and hospital discharge data for the entire Scottish population between 1995 and 2002. Participants Patients […]

Hospitalizations for Acetaminophen Overdose: a Canadian Population-Based Study From 1995-2004


Co-Proxamol and Suicide: Preventing the Continuing Toll of Overdose Deaths


Interrupted Time-Series Analysis of Regulations to Reduce Paracetamol (Acetaminophen) Poisoning


Tramadol Exposures Reported to Statewide Poison Control System


Paracetamol Related Deaths in England and Wales, 1993-97

Acetaminophen/Dextropropoxyphene: Suicide and Nonfatal Self-Poisonings

For the original study, please see SIEC #2003-0341

Non-Prescription Drugs can be Harmful: Information on Over-the-Counter Medication Abuse

Ask My Patients to Forgive Me…. (IN: Sudden Endings, by M J Meaker)