The research method in suicide studies has been primarily quantitative, and suicide remains without an adequate or accepted general theory that incorporates multiple disciplines and perspectives. Dependence on quantitative research limits an understanding of the complexity of suicide. This article argues for the use of mixed methods for suicide research. Three key topics in suicide research are highlighted: risk factors for suicide, efficacy of suicide prevention, and cultural factors in suicide and suicide prevention. Mixed methods will expand knowledge of suicide by integrating theory-based variables and subjectivity as objects of inquiry. Mixed methods will allow for a broadening of research questions, more substantive understanding, and are necessary for a multidimensional and multidisciplinary suicidology.