The objective of this scoping review is to pool together all available information regarding suicide in the spaceflight environment in order to summarize the findings in an accessible way, present data in a manner that is useful, and identify the questions that are still unanswered in this field. The PRISMA extension for scoping reviews informed the procedures of this review. Identified terms were searched across the PsycINFO, PubMed, and Scopus databases, as well as the NASA Database Open Data Portal, yielding 6049 initial manuscripts, resulting in a final selection of 0 relevant manuscripts. Secondary tar- geted searches resulted in 12 manuscripts that mentioned suicide in the spaceflight environment in some way. The suicide risk presented by the spaceflight environment may be thought of as a combination of general suicide risk factors present in the general population that may also present in the spaceflight environment, and separate suicide risk factors that are unique to the spaceflight environment. Though suicide is not a widely discussed risk for future space missions, some researchers have acknowledged it as a significant concern that should be addressed. This scoping review serves as a starting point for future research efforts to better understand and mitigate the suicide risk of the spaceflight environment.