Year: 2016 Source: International Journal of Neuropsychopharmacology.(1999).2: 105-110. SIEC No: 20160240

Alterations in thyroid axis are common in depression and subclinical hypothyroidism may predispose to recurrent depressive episodes and resistance to antidepressants. The same normal reference ranges are used in both depressive and non-psychiatric patients to detect hypothyroidism. We hypothesized that in depressive patients, serum TSH (thyrotropin) elevation within the normal reference range (≥ upper 25th percentile) may be related to patients’ characteristics reflecting the severity of the depressive illness.

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