Depressed suicide attempters have smaller hippocampus than depressed patients without suicide attempts.

Hippocampal volumes were assessed with automatic segmentation in 63 depressed patients with or without suicide attempts. Suicide attempters had lower total hippocampus volumes than non-attempters, especially for acute suicide attempts. These differences were independent from socio-demographics and major depressive disorder characteristics. A total hippocampal volume threshold of 5.00 cm3 had a 98.2% negative predictive value for acute suicide attempts. Hippocampal volume could be a suicidal state marker in major depressive episodes.

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